BIOS 6312 – Modern Biostatistics Methodology II

Announcements:  These notes have undergone substantial revision to move the examples over to R, to improve some of the illustrations (since 2019, I’ve learned that .pdf and .eps win every day of the week), and to reduce overlap with notes for other courses. Material on weighted least squares, penalized regression, and bootstrapping can be found in the notes for BIOS 7345. Material on Bayesian methods can be found in the notes for BIOS 6342 and BIOS 7345.

Syllabus: The Spring 2023 syllabus can be found here.

Lecture notes: The lecture notes for this course are posted here. They are not to be copied without permission of the instructor.

# Topic Slides
1 Review Link
2 Simple linear regression Link
3 Multiple linear regression (foundations) Link
4 Multiple linear regression (interactions, stratum effects) Link
5 Transformations and basis expansions Link
6 Binary outcomes Link
7 Nominal, ordinal, and count outcomes Link
8 Correlated data Link
9 Time-to-event outcomes Link
10 Predictive capacity of regression models Link

Labs: Links to the Spring 2023 labs are provided below. Alas, the inclusion of some Stata code in some of the labs render them obsolete in some respects.

# Date Topic Lab
1 01/12 Introduction to Stata Link
2 01/30 Prediction and diagnostics Link
3 02/06 Subgroups and omnibus tests Link
4 02/13 Transformations and nonlinearity Link
5 03/07 Discrete outcome regression Link
6 03/27 Longitudinal regression methods Link
7 04/03 Survival analysis Link
8 04/10 Penalized regression Link

Problem sets and keys: Problems for the Spring 2023 semester can be found here. Additionally, the problems from the 202 offering of this course are provided here, along with the keys.

Data: Data sets and documentation can be found here (you will need the password).

Exams: Exams are posted below, along with their keys. Note that emphasis changes from year to year, as does the ordering of topics.

Description Exam Key
Exam 1 (2020) Link Link
Exam 2 (2020) Link Link
Exam 1 (2021) Link Link
Exam 2 (2021) Link Link
Exam 1 (2022) Link Link
Exam 2 (2022) Link Link
Exam 1 (2023) Link Link
Exam 2 (2023) Link Link