Below is a list of selected publications and preprints (* denotes co-authorship). For a complete list, please see my full CV [link].
Statistics/Methodology
Spieker, A.J., Delaney, J.A.C., and McClelland,R.L. (2015). “Evaluating the treatment effects model for estimation of cross-sectional associations between risk factors and cardiovascular biomarkers influenced by medication use.” Pharmacoepidemiology and Drug Safety, 24(12), 1286-1296. [link]
Spieker, A.J. and Huang, Y. (2017). “A method to address between-subject heterogeneity for identification of principal surrogate markers in repeated low-dose challenge HIV vaccine studies.” Statistics in Medicine, 36(26), 4167-4181. [link]
Spieker, A.J., Roy, J.A., and Mitra, N. (2018). “Analyzing medical costs with time-dependent treatment: The nested g-formula.” Health Economics, 27(7), 1063-1073. [link]
Spieker, A.J., Delaney, J.A.C., and McClelland,R.L. (2018). “A method to account for covariate- specific treatment effects when estimating biomarker associations in the presence of endogenous medication use.” Statistical Methods in Medical Research, 27(8), 2279-2293. [link]
Spieker, A.J., Ko, E., Roy, J.A., and Mitra, N. (2020). “Nested g-computation: a causal approach to analysis of censored medical costs in the presence of time-varying treatment.” Journal of the Royal Statistical Society, Series C, 69(5), 1189-1208. [link] [arXiv]
Spieker, A.J., Illenberger, N., Roy, J., and Mitra, N. (2021). “Net benefit separation and the determination curve: a probabilistic framework for cost-effectiveness estimation.” Statistical Methods in Medical Research, 30(5), 1306-1319. [link] [arXiv]
Spieker, A.J., Delaney, J.A.C, and McClelland, R.L. (2021). “Semi-parametric estimation of biomarker age trends with endogenous medication use in longitudinal data.” Observational Studies, 7, 127-147. [link] [arXiv]
Nelson, L.A.*, Spieker, A.J.*, Mayberry, L.S., McNaughton, C., and Greevy, R. (2022). “Estimating the impact of engagement with digital health interventions on patient outcomes in randomized trials.” Journal of the American Medical Informatics Association, 29(1), 128-136. [link]
Spieker, A.J., Greevy, R., Nelson, L., and Mayberry, L. (2022). “Bounding the local average treatment effect in an instrumental variable analysis of engagement with a mobile intervention.” The Annals of Applied Statistics, 16(1), 60-79. [link] [arXiv]
Illenberger, N., Mitra, N., and Spieker, A.J. (2022). “A regression framework for a probabilistic measure of cost-effectiveness.” Health Economics, 31(7), 1438-1451. [link] [arXiv]
Illenberger, N., Spieker, A.J., and Mitra, N. (2022). “Identifying optimally cost-effective dynamic treatment regimes with a Q-learning approach.” Journal of the Royal Statistical Society, Series C, 72(2), 434-449. [link] [arXiv]
Spieker, A.J., Adgent, M.A., Osmundson, S.S., Phillips, S.E., Mitchel, E. Jr., Leech, A.A., Grijalva, C.G., and Wiese, A.D. (2025). “The impact of different strategies for modeling associations between medications at low doses and health outcomes: A simulation study and practical application to postpartum opioid use.” American Journal of Epidemiology, 194(1), 278-286. [link]
Dowd, N.P., Blette, B., Chappell, J.D., Halasa, N.B., and Spieker, A.J. (2025). “An overview of methods for receiver operating characteristic analysis, with an application to SARS-CoV-2 vaccine-induced humoral responses in solid organ transplant recipients.” Observational Studies, 11(2), 91-126. [link]
Applications
Spieker, A.J., Narayanaswami, P., Fleming, L., Keel, J.C., Muzin, S.C., and Rutkove, S.B. (2013). “Electrical impedance myography in the diagnosis of radiculopathy.” Muscle and Nerve 48(5), 800-805. [PubMed]
Hsi, R.S., Spieker, A.J., Stoller, M.L., Jacobs, D.R., Jr., Reiner, A.P., McClelland, R.L., Kahn, A.J., Chi, T., Szklo, M., and Sorensen, M.D. (2015). “Coronary artery calcium score and association with recurrent nephrolithiasis: the Multi-Ethnic Study of Atherosclerosis.” Journal of Urology 195(4), 971-976. [PubMed]
Nelson, L.A., Spieker A.J., Greevy, R., LeStourgeon, L.M., Wallston, K.A., and Mayberry, L.S. (2020). “User engagement remains high among diverse adults during a 12-month text message-delivered diabetes support intervention.” JMIR mHealth and uHealth, 8(7), e17534. [PubMed]
Schmidt, H.*, Spieker, A.J.*, Luo, T., Szymczak, J., and Grande, D. (2021). “Physicians and Medicaid work requirements: Variability in primary care physician attitudes toward Medicaid Work Requirement exemption requests made by patients with depression.” JAMA Health Forum, 2(10), e212932. [link]
Haddadin, Z., Schuster, J.E., Spieker, A.J., Rahman, H., Blozinski, A., Stewart, L., Campbell, A.P., Lively, J.Y., Michaels, M.G., Williams, J.V., Boom, J.A., Sahni, L.C., Staat, M., McNeal, M., Selvarangan, R., Harrison, C.J., Weinberg, G.A., Szilagyi, P.G., Englund, J.A., Klein, E.J., Curns, A.T., Rha, B., Langley, G.E., Hall, A.J., Patel, M.M., and Halasa, N.B. (2021). “Acute respiratory illnesses in children in the SARS-CoV-2 pandemic: Prospective multicenter study.” Pediatrics, 148(2), e2021051462. [PubMed]
Spieker, A.J.*, Gordetsky, J.*, Maris, A.S., Dehan, L.M., Denney, J.E., Arnold Egloff, S.A., Scarpato, K., Barocas, D., and Giannico, G.A. (2021). “PTEN expression and morphologic patterns in prostatic adenocarcinoma.” Histopathology, 79(6), 1061-1071. [PubMed]
Yanis, A.*, Haddadin, Z.*, Spieker, A.J., Waqfi, D., Talj, R., Rankin, D.A., Thomas, L., Birdwell, K.A., Ezzell, L., Blair, M., Eason, J., Varjabedian, R., Warren, C.M., Nochowicz, C.H., Olson, E.C., Simmons, J.D., Yoder, S., Guy, M., Thomsen, I., Chappell, J.D., Kalams, S.A., and Halasa, N.B. (2022) “Humoral and cellular immune responses to the SARS-Cov-2 BNT162b2 vaccine in a cohort of solid organ transplant recipients and healthy controls.” Transplant Infectious Disease, 24(1), e13772. [PubMed]
Spieker, A.J., Nelson, L.A., Rothman, R., Roumie, C., Kripilani, S., Coco, J., Fabbri, D., Levy, P., Collins, S.P., Wang, T., and McNaughton, C.D. (2022). “Feasibility and short-term effects of a multi-component emergency department blood pressure intervention: A pilot randomized trial.” Journal of the American Heart Association, 11(5), e024339. [link]
Schuster, J.E., Hamdan, L., Dulek, D.E., Kitko, C.L., Batarseh, E., Haddadin, Z., Stewart, L.S., Stahl, A., Potter, M., Rahman, H., Kalams, S.A., Coffin, S., Ardura, M.I., Wattier, R.L., Maron, G., Bocchini, C.E., Moulton, E.A., Grimley, M., Paulsen, G., Harrison, C.J., Freedman, J., Carpenter, P.A., Englund, J.A., Munoz, F.M., Danziger-Isakov, L., and Spieker, A.J.*, Halasa, N.* (2023). “Influenza vaccine in pediatric recipients of hematopoietic-cell transplants.” New England Journal of Medicine. New England Journal of Medicine , 388(4), 374-376. [link]
Selected commentaries
Spieker, A.J. “Comment on `Penalized Spline of Propensity Methods for Treatment Comparison’ by Zhou, Elliott, and Little.” (2019). Journal of the American Statistical Association. 114(S25), 20-23. [link]
Spieker, A.J. “Comments on the debate between marginal and conditional estimands.” (2022). Statistics in Medicine. 41(28), 5589-5591. [link]
Spieker, A.J. “The central role of Rosenbaum and Rubin’s seminal work” (2023). Observational Studies. 9(1), 105-112. [link]
Spieker, A.J. “Commentary: ‘Breaking tradition: should biostatistics doctoral qualifying exams evolve to better serve our students’ ability to demonstrate readiness to conduct independent research?'” (2025). Frontiers in Public Health. 13:1658570. [link]
Software